Retinal Ganglion Cell Classification and Function

Illustration of the ganglion cell types in the cat retina.

The first thorough studies of retinal ganglion cell types were performed in the cat. The researchers discovered two types of response to sine wave gratings, which (according to legend) they called “interesting” and “uninteresting”. These initial classifications resolved into the more scientifically-defensible terms X (with linear spatial summation) and Y (with non-linear spatial summation). That is, X cells fire a pattern of action potentials that matches the sine wave grating, so there are densely-clustered action potentials near the peaks of the sine wave and sparse action potentials near the troughs of the sine wave. Y cells fire a burst when the wave rises, and another when it falls. The Y cells detect when the stimulus changes; thus, if you turn on a light, the Y cells respond with a burst and then go silent until you turn the light off, when they fire another brief burst. The physiological type “X” corresponds well to the morphological type “α” and the physiological type “Y” almost matches the morphological type “β”.

The above illustration shows drawings of ganglion cells that fit into neither category and are called non-α, non-β.

 

Illustration of the ganglion cell types in the human retina.

Human ganglion cells are classified into three groups. The naming is based on historical considerations and is a bit confusing, but here goes. The three types of ganglion cells are:

  • M cells
  • P cells
  • non-M, non-P cells

In order to detect motion, retinal ganglion cells must collect information indirectly over a large portion of the retina. In particular, the ganglion cell is interested in what a large range of amacrine cells is reporting about change in change (i.e. moving edges). These ganglion cells have large dendritic trees supported by large cell bodies. They will eventually synapse onto large (magnocellular) cells in the LGN and are therefore called M ganglion cells.

In order to detect fine details, another set of retinal ganglion cells must restrict the areal extent of their inputs, collecting information indirectly from a small group of photoreceptors, horizontal cells, and amacrine cells, and directly from perhaps only one bipolar cell. This means the ganglion cell dendritic tree is small, and it is supported by a small cell body. Eventually, these will synapse onto small (parvocellular) cells in the LGN, and for this reason these ganglion cells are called P ganglion cells.

Ganglion cells which will contribute to color processing at higher levels are dumped in the bin labeled non-M, non-P.

Diagram/table of the

As we will see, this theme of specialized cells that are most interested in motion and specialized cells that are most interested in details of form will continue throughout the visual system.

 

Diagram showing how different types of ganglion cells respond to different stimuli.
Ganglion cell responses. Action potentials are represented by vertical lines in the voltage vs time traces. The stimuli that are presented while recording from the cell are shown; the yellow bar indicates that the stimulus is present. Note that the ON-center ganglion cell responds to a spot of light with a large number of action potentials. The OFF-center ganglion cell responds best to dark with a spot of light in the periphery. The ON/OFF cell responds best when the stimulus goes on or off.

Ganglion cells will convey all this information to the LGN. Since they are the only cells that send information over long distances, they are the only cells that fire action potentials. All the other types of retinal cell use graded potentials, with small fluctuations in neurotransmitter release, to convey information. (Although some amacrine cells use calcium spikes, these are not technically action potentials.)

Diagram showing the intrinsically photosensitive ganglion cell.

There are a special category of ganglion cells that have a huge dendritic tree covering a significant portion of the entire retina. These cells, the melanopsin intrinsically photosensitive ganglion cells, are responsible for telling the visual system when the sun rises in the morning and when it sets at night. That is, they respond best to changes in light not in a defined spot but over the entire visual field. These cells are important in maintaining circadian rhythms tied to day/night cycles and in the pupillary light reflex. Thus, these ganglion cells don’t send axons to the lateral geniculate but rather to the suprachiasmatic nucleus in the hypothalamus and to the olivary pretectal nucleus (near the oculomotor CN III nucleus) in the midbrain.

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Introduction to Neuroscience Copyright © by Jim Hutchins; Lindsey Aune; and Rachel Jessop is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License, except where otherwise noted.

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