Connections Between the Neuronal Membrane and Extracellular Matrix
Safina Rehman and Jim Hutchins
Chapter under construction. This is the first draft. If you have questions, or want to help in the writing or editing process, please contact hutchins.jim@gmail.com.
In between the space of the cells in our brain is what is called the extracellular matrix. This is a gel like substance that functions as the “glue” of neurons holding them in place and organizing them. It composed of a network of proteins and carbohydrates specifically collagens, elastin, proteoglycans, fibronectins, laminins, and integrins.
Collagen is a major fibrous protein that acts as a scaffold for cells.
Elastin is also a fibrous tissue that provides elasticity.
Proteoglycans are large molecules made from protein and attached sugar chains called glycosaminoglycans. It serves to fill space, resist compression, and act as a reservoir for growth factors and other signaling molecules.
https://pmc.ncbi.nlm.nih.gov/articles/PMC2675146/
