Ligand-Gated Channels

This is an outline which has not yet been turned into a first draft. If you have questions, or want to help in the writing or editing process, please contact the author: bensonbush@mail.weber.edu

Outline by Shelby Pickett and Avalon Marker

Ligand Gated Channels

• Ionotropic receptors
  • Produce EPSP: Na and K flow when ligand binds
    • Acetylcholine (nicotinic)
    • Glutamate (AMPA)
    • Glutamate (kainate)
    • Serotonin (5HT3)
  • Produce EPSP: Na, K, and Ca flow when ligand binds
    • Glutamate (NMDA type)
  • Produce IPSP: Cl flows when ligand binds
    • GABA (GABA A types
  • Ligand-gated Calcium Channels
    • There are no ligand-gated channels specifically for Ca, though nicotinic ACh receptors, 5-HT3 receptors, and all types of glutamate receptors are known as non-selective cation channels, which allow flow of Na, K, Ca, and other cations. While ACh and 5-HT3 receptors allow mostly Na & K to pass, glutamate receptors allow a significant amount of Ca to pass through.